… of a multicenter, randomized, patients-blinded two-stage clinical trial on effects of endothelial function test in patients with non-obstructive coronary artery disease  …

H Liu, G Xie, W Huang, J Liu, N Zhao… - International Journal of …, 2021 - Elsevier
… is proof-of-concept clinical trial of a disruptive endothelial … adjunctive testing of peripheral
endothelial function will result … , and that these early aggressive endothelial function-guided …

[HTML][HTML] … worsening of endothelial function and development of new digital ulcers in patients with systemic sclerosis: results from an open label, proof of concept study

K Ntelis, V Gkizas, A Filippopoulou, P Davlouros… - … Disorders, 2016 - Springer
association of the study drug with the development of new digital ulcers led to early termination
of the study… link between endothelial dysfunction and fibrosis (endothelial dysfunction → …

[HTML][HTML] Proof-of-Concept Study for an Enhanced Surrogate Marker of Endothelial Function in Diabetes

R Dalan, S Goh, S Bing, A Seneviratna, CT Phua - Scientific Reports, 2018 - nature.com
… atherosclerotic vascular disease with a higher disease burden 1 . Endothelial dysfunction
is … as per the World Health Organization criteria 21 , with normal renal function ie estimated …

Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes

S Goh, S Bing, A Seneviratna, CT Phua, R Dalan - 2018 - dr.ntu.edu.sg
… atherosclerotic vascular disease with a higher disease burden1. Endothelial dysfunction
is … type 2 diabetes in association with insulin resistance. Circulation. 101, 1780–1784 (2000). …

[HTML][HTML] Deep learning identification of coronary artery disease from bilateral finger photoplethysmography sensing: A proof-of-concept study

S Iqbal, S Agarwal, I Purcell, A Murray… - … Signal Processing and …, 2023 - Elsevier
… Blood samples were also collected giving 2 biochemical biomarkers of endothelial
function. Test sensitivities, specificities, accuracies, and Kappa statistics were determined. …

Simultaneous assessment of systemic and coronary endothelial function: can we kill two birds with one stone?

A Cardona, G Ambrosio - Circulation: Cardiovascular Imaging, 2016 - Am Heart Assoc
… In this proof of concept study right coronary artery (RCA) and internal mammary artery (IMA)
were both visualized simultaneously in 25 patients with coronary artery disease (CAD) and …

Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease

J Donate‐Correa, E Martín‐Núñez… - Journal of cellular …, 2016 - Wiley Online Library
proof-of-concept study we … vascular Klotho expression and coronary artery disease. Low
Klotho levels has been suggested as a key factor in the development of endothelial dysfunction

[HTML][HTML] … relates with carotid intima- media thickness in atherosclerotic patients with normal renal function (eGFR ≥60 mL/min/1.73m2): a proof-of-concept study

J Donate-Correa, E Martín-Núñez… - Frontiers in …, 2023 - frontiersin.org
… expression protect against endothelial dysfunction in experimental … due to clinical
atherosclerotic vascular disease. … allowed us to show associations without definitive inferences …

[HTML][HTML] Efficacy and safety of the endothelin-1 receptor antagonist macitentan in epicardial and microvascular vasospasm; a proof-of-concept study

RGT Feenstra, TPJ Jansen, MS Boekholdt… - IJC Heart & …, 2023 - Elsevier
… , a small study in patients with coronary artery disease (n = 10… in endothelial function as
per rationale of the design of this … coronary arteries in collaboration with European society of …

… pressure but not Liraglutide-mediated weight loss improves early cardiovascular disease in obstructive sleep apnea: Data from a randomized proof-of-concept study.

C O'Donnell, S Crilly, A O'Mahony, B O'Riordan… - medRxiv, 2023 - medrxiv.org
… factors and endothelial function at baseline and end of study, … (CV) diseases, such as
coronary artery disease (CAD), … real-world studies revealed a significant association of CPAP …